ABSTRACT
Sinus histiocytosis with massive lymphadenopathy is a rare histiocytic disorder with very few case reports in Indian literature. Immunological abnormalities have been documented in few cases. We report one such case of a child presenting with generalized lymphadenopathy and complicated by autoimmune hemolytic anemia, suggestive of an associated immune dysfunction.
Subject(s)
Anemia, Hemolytic/complications , Autoimmune Diseases/complications , Child , Histiocytosis, Sinus/complications , Humans , Lymphatic Diseases/complications , MaleSubject(s)
Anti-Bacterial Agents/economics , Case Management , Child , Child, Preschool , Diarrhea/economics , Female , Fluid Therapy/economics , Hospital Departments , Hospitals, Teaching , Humans , India , Infant , Male , Retrospective StudiesSubject(s)
Child, Preschool , Female , Humans , Palatal Muscles , Paralysis/etiology , Typhoid Fever/complicationsABSTRACT
An outbreak of encephalitis in Bellary district of Karnataka state and adjoining areas of Andhra Pradesh which occurred during October 1986 to January, 1987, has been investigated. Out of the 219 patients reported, 110 were from Bellary district and the remaining 109 were from Anantapur and Kurnool districts of Andhra Pradesh; 131 (59.8%) were males and 88 (40.2%) females, while 192 (87.7%) patients were aged 10 yr and below. Sixty one patients died giving a case fatality rate of 27.9 per cent. Virological/serological investigations were carried out on 153 patients. Japanese encephalitis (JE) virus was isolated from the brain tissue of 2 cases. On the basis of the results of serological tests and virus isolation, a flavivirus (JE/WN/DEN) etiology could be established in 116 (75.8%) patients.
Subject(s)
Adolescent , Child , Child, Preschool , Disease Outbreaks , Encephalitis, Japanese/epidemiology , Female , Flavivirus/isolation & purification , Humans , Incidence , India/epidemiology , Infant , Male , Togaviridae Infections/epidemiology , West Nile Fever/epidemiologyABSTRACT
One hundred and fifty cases of Japanese encephalitis (JE) in children below 12 years of age admitted to the Headquarters Hospital, Bellary Medical College during October, 1986 to January, 1987 were studied. The youngest child affected was 1 year old. The ratio of male to female was 2:1. Hindu patients (93.33%) were significantly more than Muslim patients (6.6%). The average duration of illness prior to hospitalisation was 4.2 days (SD +/- 1.9 days). Fever, headache and/or vomiting were common presenting symptoms at the onset of illness. Onset of illness was acute or sub-acute in 105 cases (70%). CSF examination showed pleocytosis with lymphocytic reaction and normal sugar. Japanese encephalitis virus was isolated from the brain biopsy tissue in one case and the seropositivity rate for JE was 50%. The mortality was 26% and was directly related to younger age, longer duration of illness prior to admission and deeper grade of coma at the time of admission. Moderate to severe sequalae were seen in 31 patients (28.82%). The mean duration of hospital stay was 8 days.